Smoking increased inflammation in chronic hepatitis C
State Hezode other reports, smoking can aggravate chronic hepatitis C patients with liver inflammation activities, but has nothing to do with the liver fibrosis. Therefore, in patients with chronic hepatitis C should be reduced by smoking or quit smoking.
To explore the smoking and chronic hepatitis C. The relationship between tissue damage, Hezode such right with histologically proven chronic hepatitis C patients with 244 cases [152 cases of male, female 92 cases; average age (45.9 ± 12.6) years] studied. Records of patients with liver biopsy within the previous month the amount of cigarettes smoked a few cigarettes per day / day, the total lifetime of smoking tobacco the number of packages per year, said package / year, according to METAIR scoring system, the liver biopsy inflammatory activity and fibrosis grade.
The results showed that inflammatory activity with the increase in the number of cigarettes smoked per day increased gradually. A2 non-smokers group of patients with moderate or severe inflammation A3 proportion of patients with 62% of daily smokers over 15 are for the 81.7% P <0.009. The total amount of lifetime smoking and the relationship between the degree of inflammatory activity is also similar, the lifetime never smokers group, 59% of patients with inflammatory activity for the A2 and A3, while smoking more than 20 bags a year were 84.6% P <0.002. Multivariate analysis showed that age over 50 years of age odds ratio was 5.4, more than 20 g alcohol per day odds ratio of 2.75, as well as more than 15 cigarettes per day odds ratio was 3.6 and the histological activity score independently associated. Fibrosis and daily cigarette consumption, or no relationship between lifetime smoking. Multivariate analysis showed that only age over 50 years of age odds ratio of 8.8, more than 30 g alcohol per day odds ratio of 3.4, as well as histological inflammatory activity score odds ratio of 7.9 were independently associated with fibrosis score, suggesting that smoking on the inflammatory activity independent of the influence and drinking.