Revealed fatty liver disease due to
The United States and other Mayo Clinic physicians Dunn conducted a cross-sectional cohort studies have shown that: According to the mean corpuscular volume (MCV), aspartate aminotransferase (AST) / alanine aminotransferase (ALT) ratio, body mass index ( BMI) and gender derived ANI index capable of identifying alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD).
Researchers in 52 cases of ALD patients and 151 cases of NAFLD patients was studied by logistic regression analysis identified distinguish between ALD and NAFLD of the four most important variable, namely, MCV, AST / ALT ratio, BMI and gender. These variables are calculated based on ANI index [ANI = 0.637 × MCV +3.91 × (AST / ALT) -0.406 × BMI +6.35 (if it is male) -58.5]. When the ANI> 0, its numerical size and the possibility of ALD diagnosis [P = eANI / (1 + eANI)] were positively correlated; as ANI <0, its numerical size and the possibility of diagnosis of NAFLD was negatively correlated.
ANI index used to distinguish between ALD and NAFLD was significantly better than the traditional indicators and recently proposed by the relevant biological markers (including the histopathological marker protein tyrosine phosphatase 1b, AST / ALT ratio, γ-Glutamine amido transferase and carbohydrate deficient transferrin, etc.).
Research suggests that: From the simple and feasible objective variables derived ANI index, can accurately identify ALD and NAFLD.