Mixed infection of hepatitis B hepatitis C
The treatment of chronic hepatitis B is still a “great difficulty”, and the mixture of chronic hepatitis B and hepatitis C infection is even more most difficult. The so-called mixed infection refers to a patient infected with the hepatitis B virus has only infected with hepatitis C virus. Survey that, B, hepatitis C infection in patients with chronic hepatitis B in the mix about 10% in patients with chronic hepatitis B is currently about 30 million, then about 300 million people in the country on the B and hepatitis C mixed infection.
Although IFN-α is the hepatitis B virus and hepatitis C virus at the same time effective drug, but the effect in practical applications far from ideal. According to the research, in the human body between the hepatitis B virus and hepatitis C virus may interact to affect the efficacy of interferon-α.
It was observed that the A, B, hepatitis C with interferon-infection, its efficacy was significantly lower than the respective single infection. When a patient after injection of recombinant interferon-α, the researchers found that hepatitis C virus is cleared, while the hepatitis B virus been activated. It was also found that application of IFN-α after the negative conversion of hepatitis B virus nucleic acid, but then appeared in hepatitis C virus nucleic acid, and there is a clear symptom as well as jaundice occurs, the patient condition aggravated. Therefore, experts do not advocate treatment with interferon-α B, hepatitis C mixed infection.
At present, the treatment of chronic hepatitis B, experts recommend the use of lamivudine, which is a nucleoside analogue, for hepatitis B virus nucleic acid significantly inhibited, it was in order to enhance the efficacy of lamivudine combined with interferon-α to the treatment of chronic hepatitis B. It stands to reason, these two drugs on the role of hepatitis B virus in different sites, the joint application should have a synergistic effect, but is not the case, both together and alone with the efficacy of lamivudine treatment of hepatitis B there was no significant difference in .
However, we found that in clinical practice, treatment of lamivudine combined with interferon-α B, hepatitis C is a better effect of mixed infection. If a patient’s transaminase perennial abnormal, at the beginning we do not know that this is an example B, hepatitis C mixed infection, the virus targets in the treatment of the review was informed of this situation. Our combination of lamivudine and interferon-α treatment for 3 months later, the effect was very satisfactory, the patient aminotransferase normal, the symptoms disappeared, and has also turned negative for hepatitis B virus nucleic acid. At this time we increase the dose of interferon-α to 500 million units / times and the results are negative conversion of hepatitis C virus nucleic acid. Followed by treatment of 3 cases of mixed infections, are to achieve “complete response.” We reasoned, could be a strong suppression of hepatitis B virus nucleic acid with lamivudine, while high-dose interferon-α is mainly inhibit hepatitis C virus nucleic acid, two drugs in the human body, “carry out their duties” and would not have a “activate” role .