HCV Fibrosis
Imperial College School of Medicine in London, Dr M Wright pointed out that the hepatitis C virus (HCV) infection in the incidence of liver fibrosis in patients with very different. To this end, the researchers explored whether the fibrosis is linear classification by disease progress, as well as the factors affecting the rate of fibrosis.
The researchers selected 917 cases received at least one liver biopsy in HCV-infected patients studied, the main use of modified HAI (Ishak) and METAVIR systems, pairs of biopsy specimens ratings. All the patients had not been treated before biopsy.
The researchers also adopted univariate and multivariate analysis to detect the demographic characteristics and the relationship between the rate of fibrosis. And through its two sub-biopsy of patients to determine whether a linear fibrosis.
It was found that male infection older, non-genotype 1 viruses are associated with faster rate of fibrosis. Multiple linear regression confirmed that these factors contribute to differences in the rate of 30% of the fibrosis.
The researchers pointed out that, METAVIR and Ishak score are highly correlated. But, in 2 patients with biopsy in 137 patients, the fibrosis score increased by 1 point predicted rate is too slow, and even a linear relationship could not be evaluated.
According to these findings, Wright Dr., leading to fibrosis, the rate of demographic characteristics of some of the difference; in assessment, Ishak and METAVIR scoring system of the same value. In addition, the clinic could not be separated by only a few years of the biopsy specimens to determine the linear relationship between fibrosis.