Genes determine the validity of hepatitis C therapy
Different hepatitis C patients received the same treatment effect is quite different, and some even lead to serious adverse reactions. A new study found that the United States, which is a gene in the human body is closely related to small changes.
Duke University, Goldstein and others 16 in “Nature” magazine published a paper online, said the human DNA (deoxyribonucleic acid) molecule has an infection linked to genes IL28B gene, when this gene base C replaced by T bases, one effect of acceptance of hepatitis C therapy, a significant change occurs.
Goldstein, who studied more than 1,600 hepatitis C patients and found that base C base T is replaced, this gene will become a “good genes”, because of the emergence of this change in patients with hepatitis C compared with no change in treatment of patients much better. With “good genes” 80% of patients with hepatitis C were cured, while the lack of “good genes” only 30% of patients with hepatitis C be cured.
Goldstein said that this was a valuable discovery, may explain why some hepatitis C patients with the treatment worked well, some people are ineffective treatment for hepatitis C patients in the future according to genes to select the appropriate method of treatment.
170 million people worldwide infected with hepatitis C, the most effective treatment for drug interferon plus ribavirin, but different results between the different, previously did not know why.