Fat is how to “settled” the liver?
Fatty liver, liver fat deposition suggests that it is too much a class of metabolic diseases, accurate to say that fatty degeneration of liver cells is the main clinical and pathological syndrome. Fatty liver can be a stand-alone primary disease, but more that some systemic diseases involving the liver’s performance, in particular, is considered an important manifestation of metabolic syndrome, so often, and diabetes, obesity, hypertension co-exist, working hand in glove with each other, adding condition.
In fact there are lipids in liver cells, fatty liver when the accumulation of these lipids in the liver wet weight of more than 5%, or pathological per unit area of 1 / 3 of the lipid droplets within the liver cells the existence of serious liver lipids of liver wet weight concentration as high as 40% ~ 50%, may be associated with or without clinical signs of liver-related. These lipids, including triglycerides, phospholipids, glycolipids or cholesterol ester and so on, but the vast majority are caused by the accumulation of triglycerides.
Then, fatty liver, is how did this happen? That is how the liver cells, lipids, excessive sediment down? The absorption and metabolism of lipids from the start with, if a large number of eating high-fat, high-cholesterol food, from the After intestinal absorption into the blood in chylomicrons increased uptake in the liver from the blood or synthetic triglycerides have increased, which is a source of triglycerides, another source is outside the liver adipose tissue, obesity and type 2 diabetes in vivo in patients with excessive peripheral fat tissue is broken down into fatty acids in lipase significant increase in liver cell uptake of free fatty acids from the blood increase, for the synthesis of triglyceride fatty acids have increased. Drinking can damage the oxidation of fatty acid utilization, is more into triglyceride deposition in the liver. Hepatocyte triglyceride synthesis was mainly with the apolipoprotein combined into the form of very low density lipoprotein transport into the blood. A variety of reasons, such as malnutrition, drugs, hepatitis and other factors can lead to very low density lipoprotein synthesis of obstacles, then the triglyceride lack of transport can not be promptly transported to the extrahepatic utilization, then the excess deposited in the liver cells, the formation of fatty liver.
Therefore, we can see that for any reason, the liver cells caused by triglyceride synthesis and secretion of very low density lipoprotein between the loss of balance, may also lead to abnormal fat deposition in liver cells, thus the formation of fatty liver.
The clinical onset of fatty liver, conceal, usually manifested asymptomatic enlargement of the liver and serum transaminases continued to rise slightly. Part of the alcohol and diabetes, fatty liver can sometimes be due to fat deposition in liver cells appear right upper abdominal discomfort or pain. Showed a small number of acute onset, often accompanied by a wide range of metabolic dysfunction, the clinical presentation was similar to acute or subacute severe viral hepatitis.
A means of diagnosis based on laboratory tests, including laboratory, B-ultrasonography and CT, if necessary, to do liver puncture. Laboratory investigations including liver function, alanine, or aspartate aminotransferase normal or mildly abnormal, GGT can be elevated, especially in alcoholic fatty liver; lipids are often higher; B super-examination showed the liver large, echo reduction, intrahepatic fat content up to more than 30% of the fatty liver can be detected in B-liver fat content of more than 50% of the fatty liver, ultrasound diagnostic sensitivity of up to 90%, B super as a non-invasive examination can be repeated inspections, especially in the course of treatment to determine the efficacy when regular inspections. CT examination because of abdominal fat and colon from gas-bearing organs such as the interference, so the diagnosis of fatty liver and its level of judging is better than B-mode ultrasound and can confirm focal fatty liver. CT examination is expensive, and there is a certain radioactive, CT examination is not a common method for diagnosis of fatty liver. Although the liver tissue examination in determining the liver inflammation, steatosis and fibrosis area compared with no horses, but because the majority of non-alcoholic steatohepatitis in patients with benign was passed by the lack of effective prevention and control measures after diagnosis and there is a certain risk, the domestic outside the liver biopsy is generally not advocated as a confirmed non-alcoholic steatohepatitis routine measures.
Treatment includes three aspects, as the “troika” – diet therapy, exercise therapy and medication. Dietary treatment is mainly to control the total calories, pay attention to diet, eat more whole grains, vegetables, eat greasy, fried and animal foods; exercise therapy can be effective in reducing visceral fat and improve insulin resistance, thereby reducing liver fat deposition , to have elevated transaminases fatty liver disease people, less activity, more rest is not a wise approach, only the appropriate strengthening exercises can promote the early resumption of liver function, exercise approach to the stride is more appropriate; for the adoption of food and exercise therapy can not improve the simple fatty liver, fatty hepatitis, and difficult to drop You need to use drug therapy in patients with high blood lipids, including lipid-lowering drugs and liver protection drugs, so far there is no convincing in view of randomized controlled trials to establish that a drug particularly effective with diabetes and hyperlipidemia of fatty liver could try polyene phosphatidyl choline, silymarin, vitamin E, lipid capsule shells, generally select one ~ two kinds of Liver drug treatment for more than six months, or to the liver function and health Indicators of normalization, and (or) imaging examination showed fatty liver receded far. Chinese medicine to prevent fatty liver disease is often played by the combined effect of traditional Chinese medicine is rich in many active ingredients, from the multi-link, multi-target regulate the body’s metabolism, and the side effects of traditional Chinese medicine’s biggest advantage is relatively small, and therefore has a wide range of applications and development prospect.