◆ Liver drugs in the treatment of fatty liver disease, is merely a supplementary measure

◆ as long as a reasonable diet, less alcohol, more exercise, rational drug use, they can stay away from fatty liver

Fatty liver, liver cells refers to accumulation of excess fat. Degree of harm caused by their accumulation, divided into three types: simple fatty liver, fatty hepatitis, fatty. From the incidence of sub-factors, fatty liver is divided into alcoholic and nonalcoholic two kinds, the former is due to excessive intake of alcohol-attributable; the latter is mainly related to obesity, and dyslipidemia and other relevant.

Non-alcoholic fatty liver disease is also a lot of harm

We often see in various media, many of the alcoholic fatty liver articles, but rarely talk about non-alcoholic fatty liver. In fact, non-alcoholic fatty liver incidence rate is not low, and the incidence rate showed an upward trend year by year, the patient is becoming a younger age. According to a statistics show that Shanghai in school the incidence of fatty liver in obese children as high as 46.7%. Ago, everyone of their importance, it would be classified as sub-healthy state, in fact, it has a lot of harm:

● At least 20% of non-alcoholic fatty liver is not simple, and has developed into steatohepatitis, cryptogenic cirrhosis, and this is an important precancerous lesion, is also one of the causes of liver failure.

● Even the simple, and its liver as compared with normal liver, but also a number of fragile, more vulnerable to drugs, industrial toxins, alcohol, ischemia, and viral infections such as injury, leading to other types of liver disease occur. Non-alcoholic fatty liver disease has become a developed country (or region) the primary cause of chronic liver disease. In addition, if the fatty liver as the liver for liver transplantation, liver transplantation is also easy to place non-functional.

● For the overweight and obese persons, fatty liver occurs, it may prompt “a vicious obesity.” Such people are very easy to concurrent dyslipidemia and disorders, diabetes, so, the probability has increased significantly. “Non-alcoholic fatty liver disease” as a disease, should arouse enough attention. Even if no symptoms, and not associated with elevated transaminase (often as simple) and fatty liver, should be a timely prevention and treatment. Appropriate prevention and treatment in the “pure” when

Sow the seeds were either farming or Zaiyang, we must choose a season. Treatment of fatty liver is also the case, when the sights were. To seize the fatty liver “simple” the prevention and control, this will greatly assist.

The term originated from fatty liver pathology, refers to diffuse fatty infiltration of the liver, depending on whether accompanied by inflammation, necrosis and fibrosis, were divided into simple fatty liver, fatty hepatitis and fatty cirrhosis of the liver. Simple fatty liver, fatty hepatitis and fatty cirrhosis of the liver disease is a gradual process of development. Simple fatty liver is a variety of liver injury in an early manifestation of toxicity, such as the timely removal of the cause and control of primary disease, mild liver fat deposition in a few months may be dissipating. If on the early intervention of simple fatty liver, which can be developed to the people dreaded by cirrhosis of the liver.

Can be seen that fatty liver is in need of treatment. Typically, doctors have an integrated approach to the treatment of fatty liver, which includes the prevention and treatment of the original disease or related risk factors, regulating diet, exercise, drugs and physical treatment. For example, intake of a balanced diet, moderate aerobic exercise, and correct harmful lifestyles and behavior, weight control. Alcoholic fatty liver patients had to quit drinking, but also the need to prevent drug abuse and other factors that may trigger liver deterioration.

Drugs: only play a supporting role in

Once the development of steatohepatitis, or accompanied by blood lipids, blood glucose, liver function and other abnormalities, in addition to the above-mentioned behavior control, still need a certain drug adjuvant therapy. Be explained that so far not found at home and abroad a panacea for the treatment of fatty liver, that is no cure for fatty liver can be removed. Existing drugs mainly for its etiology, pathogenesis, related diseases, have side effects, therefore, must be taken under the guidance of a doctor.

Weight-loss drug: For obese patients with liver disease, elevated liver enzymes weight loss can be improved, the U.S. FDA approved the use of drugs sibutramine and orlistat.

Reminded: Fatty liver in patients lose weight as quickly as possible, but the rapid weight loss but can add to liver inflammation and fibrosis, it is a weekly weight loss should not be more than 1.2 kilograms (children per week does not exceed 0.5 kg).

Insulin-sensitizing agents: Insulin resistance is one of the mechanisms of fatty liver formation, in particular associated with blood glucose abnormalities in patients with insulin-sensitizing agents, such as metformin and thiazolidinediones can improve insulin resistance, some patients receive liver tissue learn better.

Remind: This class of drugs with potential liver toxicity, liver function be monitored during drug use. In addition, metformin need to monitor the serum creatinine values during the period, who underwent surgery and the use of iodine X-ray examination before they can withdrawal.

Cholelithiasis in patients with fatty liver was significantly higher prevalence may be related to high-fat diet, obesity, diabetes, multiple metabolic disorders related; In addition, patients with fatty liver triglycerides in liver cells the imbalance between the synthesis and excretion may affect the liver the formation of abnormal bile, leading to bile in the bile salts, phospholipids, cholesterol changes in the composition of the results easy to form cholesterol gallstones. In addition, the obese patients with fatty liver in fast to lose weight, lipid-lowering therapy with fibrates could also induce the occurrence of cholelithiasis.

Clinically, patients with fatty liver complicated by cholelithiasis, once the original liver disease symptoms usually increase, resulting in significant right upper quadrant pain, liver discomfort, some patients even Biliary Colic, fever, jaundice, liver function can also be a result of concurrent cholelithiasis biliary obstruction and biliary tract infection worse. Therefore, patients with fatty liver liver does not apply to newly issued or existing liver disease-related symptoms increased vigilance should be the possibility of concurrent cholelithiasis. In view of fatty liver can be induced cholelithiasis and cholelithiasis can also exacerbate the appearance of clinical manifestations of fatty liver, so in the development of fatty liver treatment programs should take into account how to prevent the occurrence of cholelithiasis, and in dealing with cholelithiasis should also be also consider how to treat fatty liver.

A large number of clinical trials indicate that prevention and treatment of cholelithiasis does the treatment of chronic liver function through the sky effect. Danning tablets by Chinese medicine, “Shugan,” “gallbladder” for the treatment of cholelithiasis, cholelithiasis significant effect not only on, but also to improve the liver function is also a very good clinical results, prospects for the treatment of fatty liver. Similarly, the “liver can be downloaded from gall on the rule” as early as 2,000 years ago, Chinese scholars had to use bear bile (the main component ursodeoxycholic acid) in the treatment of chronic liver disease has been widely used at home and abroad in recent years, Bear deoxycholate acid, such as gallbladder Danning tablets in the treatment of fatty liver caused by a variety of reasons. In short, prevention and treatment of fatty liver and cholelithiasis, we should give priority to consider the application of ursodeoxycholic acid, bile-ning films, polyene phosphatidyl choline and other hepatobiliary diseases prevention and control of both Chinese and Western medicine, which justified because of Danning Tablet gas pass they function, especially for those who simultaneously the treatment of constipation and abdominal distension, while the polyene phosphatidylcholine also adjusted for blood lipids, preferably for the prevention and treatment of hyperlipidemia steatohepatitis.

At present the view that nourish the liver and gallbladder associated with drugs in the treatment of fatty liver damage in patients with hepatitis when the patient In addition to medication, the long-term while also adhering to the scientific way of life, and strive to achieve dietary restraint, increase exercise, reduce drinking wine and entertaining, otherwise it will rely on drugs to cure a fatty liver can still relapse.

When doctors told the thirty or forty-year-old patients with fatty liver, we should note that a reasonable diet, control diet, adequate exercise, some people think that a reasonable diet is the “ring of meat, eating cabbage to help son, He Liangshui” was in fact the opposite. Adequate amount of protein can remove the liver fat, should be guaranteed a daily intake of 80 to 100 grams (22 or so). Total eating steamed bread and rice is not only a monotone problem, for the prevention and treatment of fatty liver is not any good, it may be used oats, corn, sweet potato, bean products regulate what can not only satisfy the taste, but also very beneficial to the control of fatty liver. Because these foods contain very rich in linoleic acid, calcium, selenium, lecithin, vitamin E and more of the cellulose, can reduce serum cholesterol, triglycerides, and in the body due to excessive consumption of meat and eggs produced by toxin to maintain body acid-base balance, and may be too much intestinal fat, sugar, toxins eliminated from the body, play a lipid-lowering effect.

There are six major causes of fatty liver

Increased incidence of fatty liver, and people’s living habits, diet has a close relationship.

Cause a long-term alcohol: Alcohol is the No. 1 killer of the liver, drinking more, fatty liver, the more serious.

Excess nutrients cause 2: the excess nutrients into stored fat, can lead to obesity and fatty liver.

Malnutrition causes 3: Long-term malnutrition, lack of certain proteins and vitamins, can cause nutritional deficiency fatty liver.

4, diabetes and other causes of chronic diseases: Fatty liver in patients with type 2 diabetes incidence rate of 40% ~ 50%.

Cause of 5 drug-induced liver: drug-induced liver hepatitis accounts for 10% of adults.

6 causes hyperlipidemia: hypercholesterolemia and fatty liver in close, with the closest relationship to hypertriglyceridemia.

Focuses on prevention of fatty liver

In addition to a reasonable diet, the fatty liver patients must pay attention to dietary restraint, appropriate exercise, wise use of medication and regular medical examinations.

A moderate diet: First, to control calorie intake to lose weight to standard weight as the target, so that energy consumption is higher than energy intake.

2 appropriate exercise: Every day persist in physical training, visualization own constitution the appropriate choice of sport. Small amount of exercise should be started gradually, step by step to achieve the appropriate amount of exercise.

3 used with caution drugs: to have symptoms of fatty liver patients, in the selection of drugs must carefully guard against the toxic side effects of drugs, drugs are harmful to the liver is absolutely can not be used, to avoid further aggravating liver damage.

1, mild fatty liver concealed strong

Fatty liver is due to various causes excessive accumulation of fat in liver cells of the lesion. Fatty liver and normal liver weight accounted for 3% to 4%, if the fat content of more than 5% of liver weight shall be fatty liver, severe cases, the amount of fat up to 40% ~ 50%, fatty liver lipids are mainly triglycerides.

According to the Shanghai branch of the First People’s Hospital of Traditional Chinese Medicine, Wang Yaping, director of physician, due to fatty liver in non-infectious, no significant pain or fever performance, so the rate of early detection and early awareness rate is always low. When the hidden highly fatty liver was found, the course of the disease often has entered the stage of liver fibrosis and cirrhosis, liver metabolism had decreased to normal or even lost. At this point even if the active treatment is also difficult to pathological changes of the liver returned to normal. Therefore, the risk of fatty liver not only in the latter part of the lives and health of its great dangers, but also in its early asymptomatic covert.

    Want to know more? Please attention: Fatty liver against the “three-prescription” fat liver “phase” of you?

Second, high-risk groups need to be vigilant

No matter how well concealed fatty liver, there are always clues to prompt its existence. Fatty liver and obesity, overweight, excessive alcohol consumption, diabetes, gout, hyperlipidemia, hyperviscosity, hypercalcemia and other metabolic disorder closely related to an increase, so obese people, excessive drinkers, high-fat diet less mover, chronic liver disease and elderly endocrine patients, especially the need for regular adoption of B-ultrasound findings and see whether duration of disease and geometry. A fatty liver for clinical studies have shown that about 1 / 4 of patients with fatty liver have been co-existence of liver fibrosis, 1.5% to 8.0% of patients with cirrhosis of the liver occurs. WANG Ya-ping, director of Doctors also warned that some only a sense of fatigue or performance as a good appetite, I am pleased greasy, cholesterol, elevated triglycerides people must exercise extreme caution.

Third, symptomatic treatment programs difficult to dig up the roots

In recent years, as China’s diet and lifestyle changes in the incidence of fatty liver increasing and has become the second largest after the viral liver disease. It is reported that Shanghai, the incidence of fatty liver disease in the country, “top.” Western medicine treatment for fatty liver impressive, and symptomatic difficult to dig up the roots. And more patients with fatty liver that is not a major illness, and no need for treatment. Efforts were also made in the life of a small number of patients to reduce high-fat diet, more exercise, less alcohol. But not long-term adherence, and soon re-emerged. Laissez-faire attitude, absolutely nothing on behalf of the majority of people approach the diagnosis and treatment of fatty liver.

Beijing University of Chinese Medicine Dr. Lee expressed sorrow, when the emerging clinical liver pain, abnormal liver function, fatigue, nausea, impotence, amenorrhea and other symptoms, and even developed into liver fibrosis and early cirrhosis only when caused by patient attention, this is very regrettable.

As the mild fatty liver disease were no obvious symptoms, some people have been suffering from a fatty liver is still not known, or, even when they do not care to know, still continue to eat unhealthy lifestyles less immobile.

Is well known that the incidence of fatty liver in China in recent years been showing a rising trend, of which, work pressure, fast-paced, life does not rule, eat less activity, obesity, diabetes, high blood lipids, etc. all contribute to fatty liver in reasons.

Liver disease experts caution, fatty liver not only allow the progress of the liver itself, liver fibrosis and cirrhosis, but also often accompanied by diabetes, high blood lipids, hypertension and other chronic metabolic disorders that can lead to complications of cardiovascular diseases and death, must can not be taken lightly.

Some others in order to cast off the “fat liver” disorder medicine label. China Liver Diseases Society of fatty liver and alcoholic liver disease study group leader, the Shanghai Cooperation Group of hepatic fibrosis subjects, chief expert, Renji Hospital, Shanghai Second Medical College professor of internal medicine have been China and Germany to advise caution in these patients drugs, in particular be used with caution JiangMei drugs, diet drugs and lipid-lowering drugs. He said; taking the medication will mask JiangMei activities and the progress of liver disease, so patients with fatty liver in the etiology is not determined before the indiscriminate use, in the cause only short-term use after diagnosis. Weight-loss drugs in general there are three conditions: First, is invalid, that is, obese patients lost weight after taking less than a month and a half kilograms; 2 is a fast weight loss health hazard, that is, 1.5 kg weight loss per week adult patients for more than a week by children with more than half a kilo of weight; three are really effective, adult patients, 1.2 kg weight loss per week, children with weight loss per week and a half kilograms. Currently on the market sold a lot of weight-loss drugs belonged to the former two cases. Not determine the efficacy of current lipid-lowering drugs, and have certain side effects, first, the liver, the body arrived at the liver to the more lipid metabolism, thereby increasing the fatty liver; second, can cause muscle toxicity, muscle pain, weakness degeneration and so on; Third, after stopping to anti-lipid-hop.

Professor Zeng Minde pointed out that the universal prevention of fatty liver should be carried out without prior disease prevention has been ill earlier rule. Treatment of fatty liver of the most important way is to adjust diet and lifestyle, namely: diet, hyperactivity, easy life, less drinking, drugs used with caution. He was eating out for people to exercise prescription, the adult daily consumption of 400 grams of cereals, vegetables and 300 grams, milk, dairy products, soy products 200 grams of meat, eggs, 100 grams; trot to walk, which is 30 minutes walk 3,000 meters , trot to walk five times a week. In particular, he stressed that to eat a good breakfast, lunch want to eat, dinner, eat less and avoid eating after 0:00, because 12-point night after the body’s energy consumption self-regulation period, eating most of the food stored in the liver, is bound to increase in the incidence of fatty liver. In addition, he also warns about the alcohol intake of women is greater than 20 grams per day for men is greater than 40 grams a day can lead to alcoholic fatty liver.

Experts suggest: regular medical examinations to prevent fatty liver disease

Fatty liver has become the current state of people’s health “barometer.” Regular physical examination is to discover the most effective way to fatty liver. Imaging examination of the B-is the most commonly used detection methods, while the CT, MRI, etc. are also effective means of detection of fatty liver can be semi-quantitative monitoring of the extent of fatty liver. Liver biopsy may be diagnosed with fatty liver disease and determine the severity of their disease.

Hawthorn their sexual tepid Pickle Gan. Li’s in the “Compendium of Materia Medica,” said: its “of diet, consumption of meat product … … Xiaozhi pain of blood.” Modern pharmacological studies have shown that hawthorn can increase cardiac contractility and increase cardiac output, slowing heart rate, expansion of coronary vessels , with lower blood pressure and blood cholesterol, and so on. Edible hawthorn fruit, hawthorn cake, about 10 grams per day, two times, meal service.

Rhubarb is a bowel movement blindly diarrhea, Qingrejiedu of medicine, are generally used for acute fever of constipation. Modern pharmacological study found that its addition to diarrhea catharsis, there are also lower blood pressure, cholesterol-lowering effect. A small dressed in uniforms of obesity, hypertension, coronary heart disease, high blood lipids patients had a good effect.

Election Shanghao rhubarb, research into Ximo, encapsulated. Each 2 capsules, 2 times a day after meal service. After the service, see if it would dilute the amount of a long time, should stop taking or reduce the dosage.

Wolfberry Sweet, flat. Chinese medicine sees its Bugan yin, nourishing blood, benefits smart head. Modern pharmacological studies have shown that: wolfberry fruit can lower blood sugar, inhibiting the deposition of fat in the liver cells and promote new liver cells, and have antihypertensive effects. Every 10 to 15 grams, can be used to porridge, making dishes can also be brewed cup of tea Changyin.

System Shouwu processing system that is familiar Polygonum multiflorum. System Shouwu of temperature, taste sweetness and bitterness. Chinese believe that the system is blindly Shouwu replenishing fit, longevity of the medicine. Modern experiments confirmed that Shouwu with lowering blood pressure, lowering blood sugar, blood vessels and lower blood pressure to soften the effect. Usage: 10 ~ 15 grams per serving Jiantang, 1 ~ 2 times a day.

Cassia Cassia, also known as grass, its slightly cold, taste sweetness and bitterness. Fry use, with Liver eyesight, nourishing yin and clearing away heat, Runchang laxative effect. Modern pharmacological studies have shown that Cassia flooding agent and ethanol infusion had lower blood pressure, blood lipid and laxative effect. Usage: Each 10 grams, flood damage on behalf of the tea. Can be consumed year round, especially in the summer is appropriate.

No matter what causes liver disease, liver cell injury is a common pathological basis, the most common structural changes in both liver cytology of liver cell membrane and cell organelles within the membrane damage, thus affecting the metabolism of liver cell function and enzyme activity. Therefore, the treatment and to correct various types of liver cell injury is one of the major measures of liver disease, fatty liver membrane protective agents in the prevention and treatment of great significance. With chronic liver disease should not only the potential causes of liver injury was targeted treatment should also be said that the mother pelican carbuncle lying Hey faded apologized cochlear net book went to Po Ping Jiao massive acquisitions take along pound of coal to seek fresh real;ごhazy benches, stir over Huh bald Sword ; experts suggest that, for the treatment of fatty liver should be fighting together two lines: on the one hand effectively delay or prevent the attack factor on hepatocyte poisoning, such as the application of effective antiviral drugs to control the virus replication, complete alcohol, losing weight , disable the suspected drugs damage the liver, etc.; the other hand, should also enhance the protective function of liver cells to prevent liver cell damage and death. Membrane protective agent that is important to protect the liver cells, drugs such as polyene phosphatidyl choline (Essentiale).

In addition, patients with fatty liver must also pay attention to adjust the way daily life, so that light diet, work work and rest, to keep the spirit of joy.

This is because excessive fat accumulated in the liver, affecting the blood and nutrient supply to the liver and its own metabolism, liver cells will gradually swelling, inflammation, infiltration, degeneration and necrosis, damage liver function, leading to steatohepatitis. This situation, if long-term development, it will cause liver fibrosis and cirrhosis, which greatly increase the risk of liver cancer. Data shows that about 30% of the alcoholic fatty liver may develop cirrhosis of the liver; about 1.5 to 8.0% of the non-alcoholic fatty liver can progress to cirrhosis of the liver, this process is a short few years, or as long as several decades, and the the patient’s condition and constitution. In addition can lead to cirrhosis of the liver, the fatty liver but also with hypertension, diabetes, dyslipidemia and other “working hand in glove”, caused by coronary heart disease, stroke and other cardiovascular diseases.

Mild fatty liver disease often has no symptoms, developed to a certain stage, the patient will appear liver fullness, pain, Liang Lei rib area discomfort, fatigue, abdominal distension, anorexia, nausea and discomfort, but many mid-and late and even have patients with early liver cirrhosis is still no obvious symptoms. Therefore, symptoms alone can not determine the severity of fatty liver conditions, once diagnosed should be actively treated.

Treatment of fatty liver is stressed that individual

“Some patients with fatty liver, although it understood the dangers, but also aware of the need aggressive treatment, but to an incorrect diet, exercise methods, results, but to make sicker.” Mi Qiang said, diet, exercise is an important part of treatment of fatty liver , such as the patient should reduce the total food intake, eat high-fat, high-calorie foods, increase the coarse grains, vegetables, fruit intake, to enhance aerobic exercise. However, if diet, exercise and excessive weight loss, not only difficult to achieve the purpose, but will also affect the liver lipid metabolism, so that sicker, some have high blood pressure, coronary artery disease also is likely, therefore dangerous.

Treatment of Fatty Liver great emphasis on personalization. Diet, exercise, drugs to treat the three links, how to apply scientific and rational, it is necessary due to human illness varies and one side. City Hospital for Infectious Diseases out-patient fatty liver according to patient’s age, height, weight, etc. to calculate their daily intake of food should be the total amount allocated in accordance with the principles of nutrition, with three meals a day to develop specific recipes; based on patient condition, the body status, past medical history, formulate a reasonable exercise program to quantify the number of weekly exercise, exercise time and intensity; according to the patients color Doppler ultrasound, ALT and other tests, indicators, development of drug treatment responses. In addition, the system was established were followed up, regular return visits, timely adjustment of treatment options, monitoring the implementation of patients in order to effectively achieve the therapeutic effect.

Shanghai Sixth People’s Hospital, director of nutrition Ge Sheng told reporters that this unreasonable eating habits will add to fatty liver, because the long-term malnutrition may lead to nutritional deficiency fatty liver.

Principle should be the correct diet it is appropriate to take high-protein diet. Reduce the greasy, high-fat foods and sweets intake.

High-protein diet to avoid the loss of protein will help repair and regeneration of liver cells to prevent further damage to liver cells. Therefore, patients who are able to eat some soy products, as bean curd, dried bean curd and so on with a high protein content and low in fat characteristics.

GE, says that excessive intake of sweets, not only the heat is too high, but also excessive triglyceride synthesis in the body. Therefore, all kinds of desserts, sweet drinks, fatty liver disease should eat less. Who eat up the special sweet fruit, sugar content is high, such as grapes, Fuji apples, fatty liver disease should not eat too much.